Evidence for a slow production pathway and results for normolipidemic subjects. Stylistically, the Discussion often reads like a set of bulleted points that happen to be written out in paragraph form. Although our data seems to best fit the overlapping subnetworks model, it is only one interpretation of our results.
Future studies of the type described Phd thesis general discussion would help to refine our understanding of how the apoB-dependent LDL uptake varies with the size of the particle. SOMs were used by Suna et al and Kumpula et al. The whiteboard was an ideal medium for this task. Current Opinion in Lipidology 4: It is known that apoB changes its configuration when the lipoprotein particle changes its size, and that this configuration change affects its interaction with the LDL receptor.
A potential use of the model for diagnostic purposes was indicated but not demonstrated. Ann Int Med The different lipoprotein subfractions how many subfractions there are depends on the measurement method used should be analyzed for their biochemical constituents: However, in principle the Particle Profiler framework could be extended to include the analysis of stable isotope kinetic data.
The benefits of statins in people without established cardiovascular disease but with cardiovascular risk factors: The book suggests that you write this list with the help of a sympathetic listener who knows the project, like a supervisor.
Angptl4 upregulates cholesterol synthesis in liver via inhibition of LPL- and HL-dependent hepatic cholesterol uptake. Once I have done that, I will write my chapter in the hope that when done, I will live in hope that …. How am I going to arrange it?
A marker for cardiovascular disease risk and response to therapy.
Improved cholesterol phenotype analysis by a model relating lipoprotein life cycle processes to particle size. This model could partially explain our results, including the heterogeneous micro-architecture and the decrease of signal and noise correlations with distance.
Body mass index, waist circumference and waist: Quantifying Single Particle Lipolysis The first methodological issue is that of quantifying single particle lipolysis. They provided me absolutely an outstanding paper. Sometimes, like the null hypothesis, talking about the limitations can help you better define the contribution your study has made.
It was shown that the variables calculated by the model, can be combined to calculate sub class specific lipoprotein flux ratios that reflect disease physiology of liver and extrahepatic tissue. Effect of plasma triglyceride metabolism on lipid storage in adipose tissue: This version of the model is yet to be developed.
Lipoprotein metabolism in hepatic lipase deficiency: It is known that apoB changes its configuration when the lipoprotein particle changes its size, and that this configuration change affects its interaction with the LDL receptor.
In the third chapter, we further developed and calibrated Particle Profiler model parameters using literature data on metabolic fluxes and lipoprotein profiles from subjects with specific genetic conditions. Effects of simvastatin on apoB metabolism and LDL subfraction distribution. Like many thesis writers, Wendy has had a long slog with this project and is having trouble seeing the wood for the trees.
Should we measure routinely the LDL peak particle size? The most feasible approach to this problem would be a combination of experiments and modeling.
This gave four main findings The role of lipids and lipoproteins in atherosclerosis. The physiological and molecular regulation of lipoprotein assembly and secretion. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators.
This application showed that combining Particle Profiler-derived flux ratios with stable isotope-determined VLDL apoB production rates can be used to determine absolute VLDL production, lipolysis and uptake rates.General Discussion PhD thesis Back to PhD thesis This general discussion includes the main findings, methodological considerations related to Particle Profiler, a comparison of Particle Profiler with other modeling studies, future research recommendations and a general conclusion.
Conclusion chapter of PhD thesis.
any result of a scientific research in general should contain brief descriptions of the results and its potency and extendability to further works and augment. go here Lillis, t. discussion phd thesis general This unit will concentrate our attention before we go.
This unit will concentrate our attention before we go. This study provides evidence quali es recalls; recounts refers to an unfortunate ambiguity. Apr 18, · Writing the PhD discussion chapter: from fear to flight | the édu flâneuse - April 18, [ ] my paralysis of PhDcrastinating I found Emma Burnett’s blog posts which helpfully explained how she planned to approach her discussion chapter and also what she actually did.
Think of the Discussion chapter as an executive summary. If it is the only thing I read, I should get a good understanding of what you found and why it matters. You should explain it to me clearly, in a narrative, without restating your results.
The discussion chapter is the problem child of the thesis. The chapter most likely to provoke fear, uncertainty and doubt. Not everyone writes a chapter called "discussion", but everyone has to do discussiony bits because, well - that's where the creative magic of the PhD happens.Download